Article

Sexually dimorphic roles for the type 2 diabetes-associated <i>C2cd4b</i> gene in murine glucose homeostasis

2020-05-19

Abstract excerpt

Variants close to the VPS13C/C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies. Whilst previous functional work has suggested roles for VPS13C and C2CD4A in disease development, none has explored the role of C2CD4B . Here, we show that systemic inactivation of C2cd4b in mice leads to marked, but highly sexually dimorphic, changes in body weight and gluc...

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Literature Corpus work: 062026e0-01fd-5884-8f1c-2ea401643e3a
DOI: 10.1101/2020.05.18.099200

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Sexually dimorphic roles for the type 2 diabetes-associated <i>C2cd4b</i> gene in murine glucose homeostasisDOI 10.1101/2020.05.18.099200Read

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