Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice.

doi:10.1152/ajpendo.00074.2016

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Article

Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice.

American journal of physiology. Endocrinology and metabolism - 1 Aug 2016

Mehta Zenobia B, Fine Nicholas, Pullen Timothy J, Cane Matthew C, Hu Ming, Chabosseau Pauline, Meur Gargi, Velayos-Baeza Antonio, Monaco Anthony P, Marselli Lorella, Marchetti Piero, Rutter Guy A

Abstract excerpt

Single nucleotide polymorphisms (SNPs) close to the VPS13C, C2CD4A and C2CD4B genes on chromosome 15q are associated with impaired fasting glucose and increased risk of type 2 diabetes. eQTL analysis revealed an association between possession of risk (C) alleles at a previously implicated causal SNP, rs7163757, and lowered VPS13C and C2CD4A levels in islets from female (n = 40, P < 0.041) but not from male...

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PMID: 27329800
DOI: 10.1152/ajpendo.00074.2016
PMCID: PMC5005967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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