Article

Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism

2018-04-26

Abstract excerpt

<h4>ABSTRACT</h4> CHC22 clathrin plays a key role in intracellular membrane traffic of the insulin-responsive glucose transporter GLUT4 in humans. We performed population genetic and phylogenetic analyses of the CHC22-encoding CLTCL1 gene, revealing independent gene loss in at least two vertebrate lineages, after arising from gene duplication. All vertebrates retained the paralogous CLTC gene encoding CHC17 cla...

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Literature Corpus work: 275cc323-0ee0-5464-923d-e601af6a9784
DOI: 10.1101/307264

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