Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.

doi:10.1007/s00125-020-05350-x

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Article

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.

Diabetologia - 1 Apr 2021

Mousavy Gharavy S Neda, Owen Bryn M, Millership Steven J, Chabosseau Pauline, Pizza Grazia, Martinez-Sanchez Aida, Tasoez Emirhan, Georgiadou Eleni, Hu Ming, Fine Nicholas H F, Jacobson David A, Dickerson Matthew T, Idevall-Hagren Olof, Montoya Alex, Kramer Holger, Mehta Zenobia, Withers Dominic J, Ninov Nikolay, Gadue Paul J, Cardenas-Diaz Fabian L, Cruciani-Guglielmacci Céline, Magnan Christophe, Ibberson Mark, Leclerc Isabelle, Voz Marianne, Rutter Guy A

Abstract excerpt

AIMS/HYPOTHESIS: Variants close to the VPS13C/C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies. While previous functional work has suggested roles for VPS13C and C2CD4A in disease development, none has explored the role of C2CD4B. METHODS: CRISPR/Cas9-induced global C2cd4b-knockout mice and zebrafish larvae with c2cd4a deletion were used to study the role...

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PMID: 33492421
DOI: 10.1007/s00125-020-05350-x
PMCID: PMC7829492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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