Article

Rapid transmission and tight bottlenecks constrain the evolution of highly transmissible SARS-CoV-2 variants

2022-10-14

Abstract excerpt

Transmission bottlenecks limit the spread of novel mutations and reduce the efficiency of natural selection along a transmission chain. Many viruses exhibit tight bottlenecks, and studies of early SARS-CoV-2 lineages identified a bottleneck of 1-3 infectious virions. While increased force of infection, host receptor binding, or immune evasion may influence bottleneck size, the relationship between transmissibility...

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Literature Corpus work: 060aa144-37e7-5ac8-b0b6-5015aa14e75a
DOI: 10.1101/2022.10.12.511991

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