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Exploring Mechanism of Action of Abemaciclib in Breast Cancer Through Circulating Chromatin Fragment

2025-03-21

Abstract excerpt

<title>Abstract</title> <p>Cell free DNA (cfDNA) analysis has a large potential for cancer patient diagnosis. Given the evidence that cfDNA partially preserves chromatin architecture of tumor cells, it potentially allows the detection of tumor responses after therapeutic treatment. In this study, we aimed to detect the responses of abemaciclib, a potent cyclin-dependent kinase 4 and 6 inhibitor (CDK4/6 inhibitor)...

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Literature Corpus work
06073049-2645-5352-bf4e-564823cc887e
DOI
10.21203/rs.3.rs-5288300/v1
Open publication

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