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The interplay of circulating tumor DNA and chromatin modification, therapeutic resistance, and metastasis

8 Mar 2019

Abstract excerpt

Peripheral circulating free DNA (cfDNA) is DNA that is detected in plasma or serum fluid with a cell-free status. For cancer patients, cfDNA not only originates from apoptotic cells but also from necrotic tumor cells and disseminated tumor cells that have escaped into the blood during epithelial-mesenchymal transition. Additionally, cfDNA derived from tumors, also known as circulating tumor DNA (ctDNA), carries...

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PMID: 30849971
DOI: 10.1186/s12943-019-0989-z

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