Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis.

doi:10.1158/1078-0432.CCR-05-0327

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Article

Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2005

Fraser Scott P, Diss James K J, Chioni Athina-Myrto, Mycielska Maria E, Pan Huiyan, Yamaci Rezan F, Pani Filippo, Siwy Zuzanna, Krasowska Monika, Grzywna Zbigniew, Brackenbury William J, Theodorou Dimis, Koyutürk Meral, Kaya Handan, Battaloglu Esra, De Bella Manuela Tamburo, Slade Martin J, Tolhurst Robert, Palmieri Carlo, Jiang Jie, Latchman David S, Coombes R Charles, Djamgoz Mustafa B A

Abstract excerpt

PURPOSE: Ion channel activity is involved in several basic cellular behaviors that are integral to metastasis (e.g., proliferation, motility, secretion, and invasion), although their contribution to cancer progression has largely been ignored. The purpose of this study was to investigate voltage-gated Na(+) channel (VGSC) expression and its possible role in human breast cancer. EXPERIMENTAL DESIGN: Functional...

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PMID: 16061851
DOI: 10.1158/1078-0432.CCR-05-0327

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