Article
Emerging role for the voltage-dependent K+ channel Kv1.5 in B-lymphocyte physiology: expression associated with human lymphoma malignancy.
Journal of leukocyte biology - 1 Oct 2013
Vallejo-Gracia Albert, Bielanska Joanna, Hernández-Losa Javier, Castellví Josep, Ruiz-Marcellan M Carmen, Ramón y Cajal Santiago, Condom Enric, Manils Joan, Soler Concepció, Comes Núria, Ferreres Joan Carles, Felipe Antonio
Abstract excerpt
Kv, which play a role in the immune system, are remodeled during carcinogenesis. Leukocytes present a limited Kv repertoire, with Kv1.3 and Kv1.5 as isoforms that are involved in neoplastic processes, such as proliferation and migration. In this study, we identified Kv1.5 in B-lymphocytes, characterized its role in proliferation and migration, and analyzed Kv1.3 and Kv1.5 expression in human non-Hodgkin...
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