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Voltage-Gated Na+ Channel <i>SCN5A</i> Is a Key Regulator of a Gene Transcriptional Network That Controls Colon Cancer Invasion

22 Jul 2010

Abstract excerpt

Voltage-gated Na(+) channels (VGSC) have been implicated in the metastatic potential of human breast, prostate, and lung cancer cells. Specifically, the SCN5A gene encoding the VGSC isotype Na(v)1.5 has been defined as a key driver of human cancer cell invasion. In this study, we examined the expression and function of VGSCs in a panel of colon cancer cell lines by electrophysiologic recordings. Na(+) channel...

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PMID: 20651255
DOI: 10.1158/0008-5472.can-10-1169

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