Article
Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential: distribution and functional activity.
American journal of physiology. Cell physiology - 1 Jun 2004
Sennoune Souad R, Bakunts Karina, Martínez Gloria M, Chua-Tuan Jenny L, Kebir Yamina, Attaya Mohamed N, Martínez-Zaguilán Raul
Abstract excerpt
Tumor cells thrive in a hypoxic microenvironment with an acidic extracellular pH. To survive in this harsh environment, tumor cells must exhibit a dynamic cytosolic pH regulatory system. We hypothesize that vacuolar H(+)-ATPases (V-ATPases) that normally reside in acidic organelles are also located at the cell surface, thus regulating cytosolic pH and exacerbating the migratory ability of metastatic cells....
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