Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective autophagy controls the stability of transcription factor IRF3 to balance type I interferon production and immune suppression

31 May 2020

Abstract excerpt

IRF3 (interferon regulatory factor 3) is one of the most critical transcription factors in antiviral innate immune signaling, which is ubiquitously expressed in a variety of cells. Although it has been demonstrated that IRF3 can provoke multiple cellular processes during viral infection, including type I interferon (IFN) production, the mechanisms underlying the precise regulation of IRF3 activity are still not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cancer-related molecular mechanisms research
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32476569
DOI: 10.1080/15548627.2020.1761653

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective autophagy controls the stability of transcription factor IRF3 to balance type I interferon production and immune suppressionPMID 32476569Read ↗

TRIM-directed selective autophagy regulates immune activation.Semantic proximity Read ↗

Regulating IRFs in IFN Driven DiseaseSemantic proximity Read ↗

Autophagy gene-dependent intracellular immunity triggered by interferon-γSemantic proximity Read ↗

eIF4A3 Promotes RNA Viruses’ Replication by Inhibiting Innate Immune ResponsesSemantic proximity Read ↗

Avian TRIM13 attenuates antiviral innate immunity by targeting MAVS for autophagic degradationSemantic proximity Read ↗

Autoimmunity Risk Gene IRGM is a Master Negative Regulator of Interferon Response by Controlling the Activation of cGAS-STING and RIG-I-MAVS Signaling PathwaysSemantic proximity Read ↗

Signaling Lymphocyte Activation Molecule Family 5 Enhances Autophagy and Fine-Tunes Cytokine Response in Monocyte-Derived Dendritic Cells via Stabilization of Interferon Regulatory Factor 8Semantic proximity Read ↗

Middle East Respiratory Syndrome Coronavirus Nucleocapsid Protein Suppresses Type I and Type III Interferon Induction by Targeting RIG-I SignalingSemantic proximity Read ↗

IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradationSemantic proximity Read ↗

ISG15 driven cellular responses to virus infectionSemantic proximity Read ↗

The lysosomal LAMTOR-Rag axis functions as a checkpoint for antiviral interferon productionSemantic proximity Read ↗

2AB protein of Senecavirus A antagonizes selective autophagy and type I interferon production by degrading LC3 and MARCHF8Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.