Article

Sex-specific deubiquitylation drives immune-related neurodegeneration in <i>Drosophila</i>

2022-12-11

Abstract excerpt

<h4>Summary</h4> Risk of neurodegenerative disease such as late onset Alzheimer’s is linked to aberrant ubiquitinylation and accumulation of non-degraded proteins in brain cells. A glial network of innate immune genes modulates inflammatory responses to such protein deposition. However, vulnerability differs between the sexes. Here, we show that the Drosophila homologue of the deubiquitylase Trabid can align the...

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Literature Corpus work: 4ab76e04-c443-5ff6-8c86-8e588857607f
DOI: 10.1101/2022.12.09.519782

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