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CofActor: A light and redox-gated optogenetic clustering tool to study abnormal cytoskeletal dynamics in stressed cells

2019-11-28

Abstract excerpt

The biochemical hallmarks of neurodegenerative diseases (neural fibrils, clumps, and tangles; heightened reactive oxygen species (ROS); cofilin-actin rods) have presented numerous challenges for development of in vivo diagnostic tools (1–7). Biomarkers such as amyloid beta (Aβ) fibrils and Tau tangles in Alzheimer’s Disease (AD) are only accessible via invasive cerebrospinal fluid assay for peptide mass fingerpri...

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Literature Corpus work
05bb1a8a-e133-5014-a64a-06a7b623973a
DOI
10.1101/857706
Open publication

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