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Article

Monitoring the Response of Multiple Signal Network Components to Acute Chemo-Optogenetic Perturbations in Living Cells.

Chembiochem : a European journal of chemical biology - 16 Feb 2022

Kowalczyk Manuela, Kamps Dominic, Wu Yaowen, Dehmelt Leif, Nalbant Perihan

Abstract excerpt

Cells process information via signal networks that typically involve multiple components which are interconnected by feedback loops. The combination of acute optogenetic perturbations and microscopy-based fluorescent response readouts enables the direct investigation of causal links in such networks. However, due to overlaps in spectra of photosensitive and fluorescent proteins, current approaches that combine...

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Identifiers

PMID: 34897929
DOI: 10.1002/cbic.202100582
PMCID: PMC9303927

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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