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Drug repurposing for mitochondrial diseases using a pharmacological model of complex I deficiency in the yeast <i>Yarrowia lipolytica</i>

2020-01-09

Abstract excerpt

Mitochondrial diseases affect 1 in 5,000 live births around the world. They are caused by inherited or de novo mutations in over 350 nuclear-encoded and mtDNA-encoded genes. There is no approved treatment to stop the progression of any mitochondrial disease despite the enormous global unmet need. Affected families often self-compound cocktails of over-the-counter vitamins and generally recognized as safe nutritio...

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Literature Corpus work
0587531e-0c2b-5029-8404-06578e22dd12
DOI
10.1101/2020.01.08.899666
Open publication

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