Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ursocholanic acid rescues mitochondrial function in common forms of familial Parkinson's disease.

Brain : a journal of neurology - 1 Oct 2013

Mortiboys Heather, Aasly Jan, Bandmann Oliver

Abstract excerpt

Previous drug screens aiming to identify disease-modifying compounds for Parkinson's disease have typically been based on toxin-induced in vitro and in vivo models of this neurodegenerative condition. All these compounds have failed to have a reliable disease-modifying effect in subsequent clinical trials. We have now established a novel approach, namely to screen an entire compound library directly in patient...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Membrane Potential, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria

Share to Mutation

Share to Neurons

Share to Parkinson Disease

Share to Parkinson's Disease Mechanisms and Treatments

Share to Ursodeoxycholic Acid

Source

Identifiers

PMID: 24000005
DOI: 10.1093/brain/awt224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ursocholanic acid rescues mitochondrial function in common forms of familial Parkinson's disease.PMID 24000005Read ↗

UDCA exerts beneficial effect on mitochondrial dysfunction in LRRK2 G2019S carriers and in vivoSemantic proximity Read ↗

Mitochondrial dysfunction-targeting therapeutics of natural products in Parkinson’s diseaseSemantic proximity Read ↗

Formoterol improves the deficits of mitochondrial homeostasis including dynamic and transport in human SH-SY5Y neuroblastoma cells induced by mitochondrial UQCRC1 mutation in human neuronal SH-SY5Y cells via a β2-adrenoreceptor activationSemantic proximity Read ↗

High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagySemantic proximity Read ↗

Parkinson’s disease phenotypes in patient specific brain organoids are improved by HP-β-CD treatmentSemantic proximity Read ↗

High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy.Semantic proximity Read ↗

Rescue of mitochondrial function in parkin-mutant fibroblasts using drug loaded PMPC-PDPA polymersomes and tubular polymersomes.Semantic proximity Read ↗

A yeast-based assay identifies drugs active against human mitochondrial disorders.Semantic proximity Read ↗

Small Molecule Stabilization of PINK-1/PINK1 Improves Neurodegenerative DiseaseSemantic proximity Read ↗

A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease.Semantic proximity Read ↗

Drug repurposing for mitochondrial diseases using a pharmacological model of complex I deficiency in the yeast <i>Yarrowia lipolytica</i>Semantic proximity Read ↗

LRRK2 Attenuates Antioxidant Response in Familial Parkinson’s Disease Derived Neural Stem CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.