Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro.

doi:10.1016/j.jhep.2012.07.030

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro.

Journal of hepatology - 1 Dec 2012

Pirazzi Carlo, Adiels Martin, Burza Maria Antonella, Mancina Rosellina Margherita, Levin Malin, Ståhlman Marcus, Taskinen Marja-Riitta, Orho-Melander Marju, Perman Jeanna, Pujia Arturo, Andersson Linda, Maglio Cristina, Montalcini Tiziana, Wiklund Olov, Borén Jan, Romeo Stefano

Abstract excerpt

BACKGROUND & AIMS: The robust association between non-alcoholic fatty liver disease (NAFLD) and the genetic variant I148M (rs738409) in PNPLA3 has been widely replicated. The aim of this study was to investigate the effect of the PNPLA3 I148M mutation on: (1) hepatic secretion of very low density lipoproteins (VLDL) in humans; and (2) secretion of apolipoprotein B (apoB) from McA-RH 7777 cells, which secrete...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoproteins B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cells, Cultured

Share to Lipase

Share to Lipid Metabolism

Share to Lipoproteins, VLDL

Share to Liver

Share to Membrane Proteins

Share to Rats

Source

Open in PubMed

Identifiers

PMID: 22878467
DOI: 10.1016/j.jhep.2012.07.030

Genes

PNPLA3

Variants

rs738409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro.PMID 22878467Read ↗

PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance PathwaysSemantic proximity Read ↗

Substrate-Specific Function of PNPLA3 Facilitates Hepatic VLDL-Triglyceride Secretion During Stimulated LipogenesisSemantic proximity Read ↗

The PNPLA3 I148M variant and chronic liver disease: When a genetic mutation meets nutrientsSemantic proximity Read ↗

PNPLA3 variant M148 causes resistance to starvation-mediated lipid droplet autophagy in human hepatocytes.Semantic proximity Read ↗

Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein.Semantic proximity Read ↗

Hepatic patatin-like phospholipase domain-containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans.Semantic proximity Read ↗

Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function.Semantic proximity Read ↗

The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamicsSemantic proximity Read ↗

Function of PNPLA3 I148M-Lessons From In Vivo Studies in Humans.Semantic proximity Read ↗

Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans.Semantic proximity Read ↗

The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans.Semantic proximity Read ↗

The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.