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A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo

2020-03-31

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<h4>ABSTRACT</h4> Tracking DNA double strand break (DSB) repair is paramount for the understanding and therapeutic development of various diseases including cancers. Herein, we describe a multiplexed bioluminescent repair reporter (BLRR) for non-invasive monitoring of DSB repair pathways in living cells and animals. The BLRR approach employs secreted Gaussia and Vargula luciferases to simultaneously detect homo...

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Literature Corpus work: 5d2bc58d-0b2e-5f78-aeba-4abb42483454
DOI: 10.1101/2020.03.30.015271

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A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivoDOI 10.1101/2020.03.30.015271Read

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A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics <i>in vitro</i> and <i>in vivo</i>

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