Article

Investigating the role of genomic drivers of MET pathway dysregulation in the heterogeneity of pleomorphic lung carcinoma

2019-01-01

Abstract excerpt

Background: Pleomorphic Lung Carcinoma (PC) is a rare lung cancer that is aggressive and poorly responsive to treatments. It is a highly heterogenous tumour and unique as it has at least 10% dedifferentiated sarcomatoid component alongside its epithelial components. Recent data have demonstrated a high frequency of mutations in the MET receptor that may support epithelial to mesenchymal transition (EMT) as an impo...

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Literature Corpus work: 0544b887-43cf-5a58-a94d-1c05dbef89c7
DOI: 10.25560/78719

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