Pulmonary Sarcomatoid Carcinomas Commonly Harbor Either Potentially Targetable Genomic Alterations or High Tumor Mutational Burden as Observed by Comprehensive Genomic Profiling.

doi:10.1016/j.jtho.2017.03.005

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Article

Pulmonary Sarcomatoid Carcinomas Commonly Harbor Either Potentially Targetable Genomic Alterations or High Tumor Mutational Burden as Observed by Comprehensive Genomic Profiling.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jun 2017

Schrock Alexa B, Li Shuyu D, Frampton Garrett M, Suh James, Braun Eduardo, Mehra Ranee, Buck Steven C, Bufill Jose A, Peled Nir, Karim Nagla Abdel, Hsieh K Cynthia, Doria Manuel, Knost James, Chen Rong, Ou Sai-Hong Ignatius, Ross Jeffrey S, Stephens Philip J, Fishkin Paul, Miller Vincent A, Ali Siraj M, Halmos Balazs, Liu Jane J

Abstract excerpt

INTRODUCTION: Pulmonary sarcomatoid carcinoma (PSC) is a high-grade NSCLC characterized by poor prognosis and resistance to chemotherapy. Development of targeted therapeutic strategies for PSC has been hampered because of limited and inconsistent molecular characterization. METHODS: Hybrid capture-based comprehensive genomic profiling was performed on DNA from formalin-fixed paraffin-embedded sections of 15,867...

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PMID: 28315738
DOI: 10.1016/j.jtho.2017.03.005

Genes

MET
BRAF
EGFR
KRAS
RET

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