Article
Malignant Transformation in Pleomorphic Adenoma: The Impact of DNA Methylation Profiling and Pathogenic Mutations.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 2025
Uro-Coste Emmanuelle, Nicaise Yvan, Akiki Béatrice, Decamps Clementine, Chaltiel Léonor, Siegfried Aurore, Herbault-Barres Beatrice, Reboul Hadrien, Bassey Emmanuella, Modesto Anouchka, Poissonnet Valentine, Even Caroline, Verillaud Benjamin, Costes-Martineau Valérie, Ferrand François-Regis, Vergez Sebastien, Cohen-Jonathan-Moyal Elizabeth
Abstract excerpt
Salivary gland tumors are a rare and heterogeneous group of lesions with diverse microscopic appearances and variable clinical behavior. The most common salivary gland tumor subtype, pleomorphic adenoma (PA), can undergo malignant transformation into carcinoma ex pleomorphic adenoma (CXPA). Carcinomatous transformation from PA to CXPA is a highly progressive and multistep process. Distinguishing a PA with some...
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