Article
Genomic origin and intratumor heterogeneity revealed by sequencing on carcinomatous and sarcomatous components of pulmonary sarcomatoid carcinoma.
Oncogene - 1 Jan 2021
Liu Xuewen, Wang Fang, Xu Chunwei, Chen Xinru, Hou Xue, Li Qian, Li Pansong, Xie Zhi, Liu Yongdong, Chang Lianpeng, Guan Yanfang, Zhang Xuchao, Yang Ling, Wang Hui, Yi Xin, Zhang Jianjun, Xia Xuefeng, Moran Cesar, Chen Likun
Abstract excerpt
Pulmonary sarcomatoid carcinoma (PSC) contains carcinomatous component (CaC) and sarcomatous component (SaC). Herein, we explored the genomic origin and intratumor heterogeneity (ITH) of PSC. We collected 31 resected PSC tumors and obtained CaC and SaC by laser capture microdissection for next-generation sequencing. The majority of PSCs (97%) had component-shared alterations. Driver mutations in EGFR, KRAS, MET,...
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