Comprehensive molecular profiling of lung adenocarcinoma.

doi:10.1038/nature13385

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Article

Comprehensive molecular profiling of lung adenocarcinoma.

Nature - 31 Jul 2014

Abstract excerpt

Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. High rates of somatic mutation were seen (mean 8.9 mutations per megabase). Eighteen genes were statistically significantly mutated, including RIT1...