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Article

Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma.

Nature communications - 28 Sept 2020

Yang Zhenlin, Xu Jiachen, Li Lin, Li Renda, Wang Yalong, Tian Yanhua, Guo Wei, Wang Zhijie, Tan Fengwei, Ying Jianming, Jiao Yuchen, Gao Shugeng, Wang Jie, Gao Yibo, He Jie

Abstract excerpt

Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of lung cancer with poor prognosis. Here, we perform multi-omics analysis of 56 PSC samples, 14 of which are microdissected to analyze intratumoral heterogeneity. We report the mutational landscape of PSC. The epithelial and sarcomatoid components share numerous genomic alterations, indicating a common progenitor. We find that epithelial-mesenchymal...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32985499
DOI: 10.1038/s41467-020-18702-3
PMCID: PMC7522294

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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