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Article

Use of multiple pharmacodynamic measures to deconstruct the Nix-TB regimen in a short-course murine model of tuberculosis

19 Mar 2024

Abstract excerpt

ABSTRACT A major challenge for tuberculosis (TB) drug development is to prioritize promising combination regimens from a large and growing number of possibilities. This includes demonstrating individual drug contributions to the activity of higher-order combinations. A BALB/c mouse TB infection model was used to evaluate the contributions of each drug and pairwise combination in the clinically relevant Nix-TB...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38501805
DOI: 10.1128/aac.01010-23

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