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Article

Strain diversity drives heterogeneous responses to tuberculosis combination therapy.

Antimicrobial agents and chemotherapy - 3 Jun 2026

Yoon Michelle H, Culviner Peter H, Pereira Moraes Mariana, Nitta Hidetomi, Thuong Nguyen Thuy Thuong, Fortune Sarah M, Aldridge Bree B

Abstract excerpt

Strain diversity in Mycobacterium tuberculosis (Mtb) underlies distinct clinical presentations and outcomes, but the range of drug susceptibility phenotypes among clinical isolates is poorly understood. We aimed to identify drug response patterns in phylogenetically diverse clinical isolates to combination treatment. We selected 13 strains out of 641 drug-sensitive clinical isolates that capture local and global...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42138375
DOI: 10.1128/aac.01849-25
PMCID: PMC13182990

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