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Article

Immune Cytolytic Activity Stratifies Molecular Subsets of Human Pancreatic Cancer

23 Dec 2016

Abstract excerpt

Abstract Purpose: Immunotherapy has the potential to improve the dismal prognosis in pancreatic ductal adenocarcinoma (PDA), but clinical trials, including those with single-agent PD-1 or PD-L1 inhibition, have been disappointing. Our aim was to examine the immune landscape of PDA as it relates to aspects of tumor biology, including neoepitope burden. Experimental Design: We used publicly available expression...

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PMID: 28007776
DOI: 10.1158/1078-0432.ccr-16-2128

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