Article

Hypoxic Conditions Confer Chemoresistance to Crizotinib but Not to Imatinib in Chronic Myeloid Leukemia (CML) Cells Depending on HIF1α and JAK2

2023-09-19

Abstract excerpt

Chronic myeloid leukemia (CML) is the most common form of leukemia in adults and accounts for approximately 15% of all leukemia cases. The etiology of this disease is based on the presence of the oncogenic Bcr/Abl fusion protein, which has dysregulated tyrosine kinase activity. This pathological condition is the result of a chromosomal translocation between chromosomes 9 and 22 leading to the formation of the Phil...

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Literature Corpus work: 053436c1-bd45-53ac-947f-9b510faef48a
DOI: 10.20944/preprints202309.1256.v1

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