Article
JAK2V617F reprograms Hypoxia Inducible Factor-1 to induce a non-canonical hypoxia regulon in myeloproliferative neoplasms.
Leukemia - 1 Mar 2026
Kealy David, Ellerington Ruth, Bansal Suraj, Medeiros Jessie J F, Hawley Catherine A, Zeng Andy G X, Lukaszonek Jakub, West Katie A, Sinha Aparna D, Caalim Gillian, Gawne Richard T, Pope Jacob, Ferreira Bianca Lima, Blacknell Nicole-Mae, Drylie Bryce, Chatzigerou Jenny, Khoo Hwei Minn, Wilkinson Adam C, Fielding Adele K, Wang Guanlin, Psaila Bethan, Kent David G, Hitchcock Ian S, Holding Andrew N, Mason Andrew S, Gupta Vikas, Dick John E, Bridge Katherine S
Abstract excerpt
Hypoxia-inducible factors (HIFs) are master transcriptional regulators, central to cellular survival in hypoxia and frequently activated within malignancy. Whilst malignant context directs the role of HIFs within oncogenesis, these mechanisms are not well characterised. Applying the JAK2V617F myeloproliferative neoplasms (MPNs) oncogene-driver model, in which HIF-1α is stabilised in normoxia (20% O2), we sought...
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