Article

ATRX loss in sarcomas is associated with dysregulated gene and transposable element expression, loss of DNA methylation, and worse survival

2025-11-17

Abstract excerpt

<h4>Background</h4> ATRX is a tumor suppressor and key regulator of transcriptionally repressive epigenetic states. We investigate the impact of ATRX loss on gene expression, DNA methylation, and transposable element (TE) expression in common soft tissue sarcoma tumors, a family of rare cancers. <h4>Methods</h4> Using data from The Cancer Genome Atlas (TCGA), we analyzed 234 tumors from patients with dedifferen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0522d86a-6a1c-5460-b476-5cbbe9b99bec
DOI: 10.1101/2025.11.13.25340146

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ATRX loss in sarcomas is associated with dysregulated gene and transposable element expression, loss of DNA methylation, and worse survivalDOI 10.1101/2025.11.13.25340146Read

ATRX alteration contributes to tumor growth and immune escape in pleomorphic sarcomasSemantic proximity Read

ATRX Alteration Contributes to Tumor Growth and Immune Escape in Pleomorphic SarcomasSemantic proximity Read

Integrative genomic and transcriptomic analysis of leiomyosarcoma.Semantic proximity Read

Immune checkpoint inhibitor response in sarcomas associates with immune infiltrates and increased expression of transposable elements and viral response pathwaysSemantic proximity Read

Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas.Semantic proximity Read

The epigenomics of sarcoma.Semantic proximity Read

Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomasSemantic proximity Read

Integrated Genomic and Transcriptomic Analysis Revealed Mutation Patterns of De-differentiated Liposarcoma and LeiomyosarcomaSemantic proximity Read

Integrated genetic and epigenetic analysis of myxofibrosarcoma.Semantic proximity Read

Integrated genomic and transcriptomic analysis revealed mutation patterns of de-differentiated liposarcoma and leiomyosarcoma.Semantic proximity Read

Spatially-Resolved Multiomic Atlas of Leiomyosarcoma Identifies Two Clinically Relevant Epigenetically-Driven Cell StatesSemantic proximity Read

Epigenetic targeting of PGBD5-dependent DNA damage in SMARCB1-deficient sarcomasSemantic proximity Read