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Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas

17 Dec 2013

Abstract excerpt

BACKGROUND: High-grade soft tissue sarcomas are a heterogeneous, complex group of aggressive malignant tumors showing mesenchymal differentiation. Recently, soft tissue sarcomas have increasingly been classified on the basis of underlying genetic alterations; however, the role of aberrant DNA methylation in these tumors is not well understood and, consequently, the usefulness of methylation-based classification...

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PMID: 24345474
DOI: 10.1186/gb-2013-14-12-r137

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