Article

Repurposing mitochondrial-targeting anthelmintic agents with GLUT1 inhibitor BAY-876 for cancer therapy

2024-05-05

Abstract excerpt

<h4>ABSTRACT</h4> Cancer cells alter their metabolic phenotypes with nutritional change. Single agent approaches targeting mitochondrial metabolism in cancer have failed due to either dose limiting off target toxicities, or lack of efficacy in vivo . To mitigate these clinical challenges, we investigated the potential utility of repurposing FDA approved mitochondrial targeting anthelmintic agents, niclosamide an...

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Literature Corpus work: 18495dfb-492c-5de8-b6e0-a00a446903bd
DOI: 10.1101/2024.05.02.592272

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