Article

Reprogramming the neuroblastoma epigenome with a mitochondrial uncoupler

2021-09-06

Abstract excerpt

Dysregulated DNA methylation is associated with poor prognosis in cancer patients, promoting tumorigenesis and therapeutic resistance 1 . DNA methyltransferase inhibitors (DNMTi) reduce DNA methylation and promote cancer cell differentiation, with two DNMTi already approved for cancer treatment 2 . However, these drugs rely on cell division to dilute existing methylation, thus the ‘demethylation’ effects are ach...

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Literature Corpus work: 7e2d30e3-1b64-5198-879f-ef9f50bbb3a3
DOI: 10.1101/2021.09.05.459035

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