Article

Formation of templated inclusions in a forebrain α-synuclein mouse model is independent of LRRK2

2023-08-20

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) and α-synuclein share enigmatic roles in the pathobiology of Parkinson’s disease (PD). LRRK2 mutations are a common genetic cause of PD which, in addition to neurodegeneration, often present with abnormal deposits of α-synuclein in the form of Lewy-related pathology. As Lewy-related pathology is a prominent neuropathologic finding in sporadic PD, the relationship between LRRK2...

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Literature Corpus work: 051421fd-01cc-5f8a-8265-48fb61803023
DOI: 10.1101/2023.08.19.553965

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