Article

Regional and cellular iron deposition patterns predict clinical subtypes of multiple system atrophy

2023-09-06

Abstract excerpt

<title>Abstract</title> <p>Background Multiple system atrophy (MSA) is a primary oligodendroglial synucleinopathy, characterized by elevated iron burden in early-affected subcortical nuclei. Although neurotoxic effects of brain iron deposition and its reciprocal relationship with α-synuclein pathology have been demonstrated, the exact role of iron dysregulation in MSA pathogenesis is unknown. In this regard, adv...

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Literature Corpus work: 04efd234-c8f3-5ac3-bc18-648f8e1505b2
DOI: 10.21203/rs.3.rs-3296997/v1

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