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Article

Heterogeneity of Multiple System Atrophy: An Update

3 Mar 2022

Abstract excerpt

Multiple system atrophy (MSA) is a fatal, rapidly progressing neurodegenerative disease of uncertain etiology, clinically characterized by various combinations of Levodopa unresponsive parkinsonism, cerebellar, autonomic and motor dysfunctions. The morphological hallmark of this α-synucleinopathy is the deposition of aberrant α-synuclein in both glia, mainly oligodendroglia (glial cytoplasmic inclusions /GCIs/)...

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PMID: 35327402
DOI: 10.3390/biomedicines10030599

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