Ocular immune privilege in action: the living eye imposes unique regulatory and anergic gene signatures on uveitogenic T cells

Abstract excerpt

SUMMARY Despite ocular immune privilege, circulating retina-specific T cells can trigger autoimmune uveitis, yet intraocular bleeding-a relatively common event-rarely leads to disease. Using an in vivo immune privilege model, we previously reported that all naive retina-specific T cells entering the eye become primed in situ; about 30% become Foxp3+ T-regulatory cells (Tregs), while the rest fail to induce patholo...

Topics

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• Disease Models, Animal
• Fibroblasts
• Graves Ophthalmopathy
• Inflammation
• Mice
• Receptors, Thyrotropin
• T-Lymphocytes, Cytotoxic
• T-Lymphocytes, Regulatory

Identifiers and source

Literature Corpus work

04eac2b7-0897-5469-b28c-6612dc1045bc

DOI

10.1101/2025.03.01.640701