Article

Human cornea harbors tissue-resident memory T cells shaped by systemic immune activation, age and biological sex

2026-07-24

Abstract excerpt

The cornea is classically regarded as an immune-privileged tissue. However, recent studies have identified T cells in the healthy human cornea that are absent in specific pathogen-free (SPF) mice. The identity of these T cells, the systemic cues that drive their establishment, and the molecular mechanisms governing their corneal homing remain unknown. Here, we combine multimodal human data with tractable murine mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e4e66697-dfd1-5735-98e2-47fc2364706b
DOI: 10.64898/2026.07.20.739463

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human cornea harbors tissue-resident memory T cells shaped by systemic immune activation, age and biological sexDOI 10.64898/2026.07.20.739463Read

Tissue resident memory T cells populate the human uveal tractSemantic proximity Read

Transcriptional profiling and single-cell chimerism analysis identifies human tissue resident T cells in the human skin after allogeneic stem cell transplantationSemantic proximity Read

Functional heterogeneity of human skin-resident memory T cells in health and disease.Semantic proximity Read

Time- and Stimulus-Dependent Characteristics of Innate Immune Cells in Organ-Cultured Human Corneal TissueSemantic proximity Read

Twenty-five–Year Panorama of Corneal ImmunologySemantic proximity Read

Antigen-presenting cells are stratified within normal human corneas and are rapidly mobilized during ex vivo viral infection.Semantic proximity Read

Tissue-resident memory T cells.Semantic proximity Read

Ocular immune privilege in action: the living eye imposes unique regulatory and anergic gene signatures on uveitogenic T cellsSemantic proximity Read

Immune Privilege: The Microbiome and Uveitis.Semantic proximity Read

Spatiotemporal single-cell analysis elucidates the cellular and molecular dynamics of human cornea agingSemantic proximity Read

Tegument-Specific, Virus-Reactive CD4 T Cells Localize to the Cornea in Herpes Simplex Virus Interstitial Keratitis in HumansSemantic proximity Read

An update on our understanding of host defense mechanisms at the ocular surface; innate immune dysregulation at the ocular surface: lessons from Stevens-Johnson syndrome and related inflammatory disorders.Semantic proximity Read