Article
Insights on the Mechanism of Action of INH-C10 as an Antitubercular Prodrug.
Molecular pharmaceutics - 4 Dec 2017
Vila-Viçosa Diogo, Victor Bruno L, Ramos Jorge, Machado Diana, Viveiros Miguel, Switala Jacek, Loewen Peter C, Leitão Ruben, Martins Filomena, Machuqueiro Miguel
Abstract excerpt
Tuberculosis remains one of the top causes of death worldwide, and combating its spread has been severely complicated by the emergence of drug-resistance mutations, highlighting the need for more effective drugs. Despite the resistance to isoniazid (INH) arising from mutations in the katG gene encoding the catalase-peroxidase KatG, most notably the S315T mutation, this compound is still one of the most powerful...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.