Article

Oncoprotein CIP2A controls PKM2 dimer-tetramer transition through phosphorylation of serine 287 in non-small cell lung cancer

2022-01-19

Abstract excerpt

<title>Abstract</title> <p>Dimer-tetramer transition determines the pyruvate kinase activity of pyruvate kinase M2 (PKM2), the final rate-limiting enzyme in glycolysis. Several small molecules have been shown to be able to promote PKM2 confirmation change, but the role of oncoproteins including the cancerous inhibitor of protein phosphatase PP2A (CIP2A) that is overexpressed in most human malignancies, in PKM2 di...

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Literature Corpus work: 9423b2df-0ec2-568c-80f8-f1391c6e0d0a
DOI: 10.21203/rs.3.rs-1232624/v1

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