Article
A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.
Cancer cell - 9 Nov 2015
Cannell Ian G, Merrick Karl A, Morandell Sandra, Zhu Chang-Qi, Braun Christian J, Grant Robert A, Cameron Eleanor R, Tsao Ming-Sound, Hemann Michael T, Yaffe Michael B
Abstract excerpt
In normal cells, p53 is activated by DNA damage checkpoint kinases to simultaneously control the G1/S and G2/M cell cycle checkpoints through transcriptional induction of p21(cip1) and Gadd45α. In p53-mutant tumors, cell cycle checkpoints are rewired, leading to dependency on the p38/MK2 pathway to survive DNA-damaging chemotherapy. Here we show that the RNA binding protein hnRNPA0 is the "successor" to p53 for...
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