Article

A cryo-EM structure of metazoan TRAPPIII, the multisubunit complex that activates the GTPase Rab1

2020-12-17

Abstract excerpt

<h4>Summary</h4> The TRAPP complexes are highly conserved nucleotide exchange factors, with TRAPPIII activating Rab1 and TRAPPII acting primarily on Rab11. The two complexes share a core of small subunits that affect nucleotide exchange, but are distinguished by additional large subunits that are essential for activity in vivo, and are mutated in a range of human disorders. Crystal structures of the core subunits...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4acfd458-f2c4-5669-be6b-f5481dee787d
DOI: 10.1101/2020.12.17.423307

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A cryo-EM structure of metazoan TRAPPIII, the multisubunit complex that activates the GTPase Rab1DOI 10.1101/2020.12.17.423307Read

Cryo‐EM structure of metazoan TRAPPIII, the multi‐subunit complex that activates the GTPase Rab1Semantic proximity Read

TRAPPopathies: Severe Multisystem Disorders Caused by Variants in Genes of the Transport Protein Particle (TRAPP) Complexes.Semantic proximity Read

R2TP-like Quaternary Chaperones: a comprehensive overview to understand the dynamic R2SP complexSemantic proximity Read

Integrative modeling reveals the molecular architecture of the Intraflagellar Transport A (IFT-A) complexSemantic proximity Read

A Modified TurboID Approach Identifies Tissue-Specific Centriolar Components In <i>C. elegans</i>Semantic proximity Read

The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering.Semantic proximity Read

<i>Tetrahymena</i> Poc5 is a transient basal body component that is important for basal body maturationSemantic proximity Read

A TRAPPC2L/TRAPPC11/12/13 subcomplex directs TRAPPIII to autophagySemantic proximity Read

Structural and functional studies of the first tripartite protein complex at the <i>Trypanosoma brucei</i> flagellar pocket collarSemantic proximity Read

An amino acid-resolution interactome for motile cilia illuminates the structure and function of ciliopathy protein complexesSemantic proximity Read

Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors.Semantic proximity Read

The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs.Semantic proximity Read