Article

Multiple Ciliary Localization Signals Control INPP5E Ciliary Targeting

2022-01-26

Abstract excerpt

<h4>ABSTRACT</h4> Primary cilia are sensory membrane protrusions whose dysfunction causes diseases named ciliopathies. INPP5E is a ciliary phosphoinositide phosphatase mutated in ciliopathies like Joubert syndrome. INPP5E regulates numerous ciliary functions, such as cilium stability, trafficking, signaling, or exovesicle release. Despite its key ciliary roles, how INPP5E accumulates in cilia remains poorly under...

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Literature Corpus work: d85a00e5-da9a-5384-8c98-aa3c6341c23d
DOI: 10.1101/2022.01.25.477585

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