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Evidence Supporting a Role for TopBP1 and Brd4 in the Initiation but Not Continuation of Human Papillomavirus 16 E1/E2-Mediated DNA Replication

19 Feb 2015

Abstract excerpt

UNLABELLED: To replicate the double-stranded human papillomavirus 16 (HPV16) DNA genome, viral proteins E1 and E2 associate with the viral origin of replication, and E2 can also regulate transcription from adjacent promoters. E2 interacts with host proteins in order to regulate both transcription and replication; TopBP1 and Brd4 are cellular proteins that interact with HPV16 E2. Previous work with E2 mutants...

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PMID: 25694599
DOI: 10.1128/jvi.00335-15

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Evidence Supporting a Role for TopBP1 and Brd4 in the Initiation but Not Continuation of Human Papillomavirus 16 E1/E2-Mediated DNA ReplicationPMID 25694599Read ↗

An Interaction between Human Papillomavirus 16 E2 and TopBP1 Is Required for Optimum Viral DNA Replication and Episomal Genome EstablishmentSemantic proximity Read ↗

Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation functionSemantic proximity Read ↗

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Why Human Papillomaviruses Activate the DNA Damage Response (DDR) and How Cellular and Viral Replication Persists in the Presence of DDR SignalingSemantic proximity Read ↗

TopBP1 Regulates Human Papillomavirus Type 16 E2 Interaction with ChromatinSemantic proximity Read ↗

DNA Damage Reduces the Quality, but Not the Quantity of Human Papillomavirus 16 E1 and E2 DNA Replication.Semantic proximity Read ↗

Human papillomavirus 16 E2 interaction with TopBP1 is required for E2 and viral genome stability during the viral life cycleSemantic proximity Read ↗

The Cellular DNA Helicase ChlR1 Regulates Chromatin and Nuclear Matrix Attachment of the Human Papillomavirus 16 E2 Protein and High-Copy-Number Viral Genome Establishment.Semantic proximity Read ↗

Human Papillomavirus 16 E2 Interaction with TopBP1 Is Required for E2 and Viral Genome Stability during the Viral Life CycleSemantic proximity Read ↗

Brd4 Is Required for E2-Mediated Transcriptional Activation but Not Genome Partitioning of All PapillomavirusesSemantic proximity Read ↗

E2 displacement of CIP2A from TOPBP1 activates the DNA damage response during papillomavirus life cyclesSemantic proximity Read ↗

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