Article
High-Throughput DNA Sequencing Analysis of Antibody Repertoires.
Microbiology spectrum - 1 Oct 2014
Boyd Scott D, Joshi Shilpa A
Abstract excerpt
New high-throughput DNA sequencing (HTS) technologies developed in the past decade have begun to be applied to the study of the complex gene rearrangements that encode human antibodies. This article first reviews the genetic features of Ig loci and the HTS technologies that have been applied to human repertoire studies, then discusses key choices for experimental design and data analysis in these experiments and...
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