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Article

GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant.

Neurobiology of disease - 1 Oct 2017

Giddens Michelle M, Wong Jennifer C, Schroeder Jason P, Farrow Emily G, Smith Brilee M, Owino Sharon, Soden Sarah E, Meyer Rebecca C, Saunders Carol, LePichon J B, Weinshenker David, Escayg Andrew, Hall Randy A

Abstract excerpt

Progressive myoclonus epilepsies (PMEs) are disorders characterized by myoclonic and generalized seizures with progressive neurological deterioration. While several genetic causes for PMEs have been identified, the underlying causes remain unknown for a substantial portion of cases. Here we describe several affected individuals from a large, consanguineous family presenting with a novel PME in which symptoms...

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Source

Open in PubMed Open full text

Identifiers

PMID: 28688853
DOI: 10.1016/j.nbd.2017.07.006
PMCID: PMC5569905

Genes

GPR37

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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