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Article

Regulation of histone H3K4 methylation in brain development and disease.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 26 Sept 2014

Shen Erica, Shulha Hennady, Weng Zhiping, Akbarian Schahram

Abstract excerpt

The growing list of mutations implicated in monogenic disorders of the developing brain includes at least seven genes (ARX, CUL4B, KDM5A, KDM5C, KMT2A, KMT2C, KMT2D) with loss-of-function mutations affecting proper regulation of histone H3 lysine 4 methylation, a chromatin mark which on a genome-wide scale is broadly associated with active gene expression, with its mono-, di- and trimethylated forms...

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Source

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Identifiers

PMID: 25135975
DOI: 10.1098/rstb.2013.0514
PMCID: PMC4142035

Genes

ARX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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