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Genotypic and Phenotypic Profile of 50 Cases With Chromatin Remodeling Complexes-Related Neurological Disorders.

CNS neuroscience & therapeutics - 1 Aug 2026

Chen Shimeng, Yin Fei, He Fang, Zhang Ciliu, Deng Xiaolu, Yang Lifen, Yang Li, Chen Chen, Liu Fangyun, Peng Jing

Abstract excerpt

AIM: To describe the genotypic and phenotypic profile of chromatin remodeling complex (CRC)-related neurological disorders. METHODS: We retrospectively analyzed the clinical characteristics and the genetic spectrum of children with variants in CRC genes. RESULTS: Fifty patients were included. The genotype spectrum involved genes encoding the CHD complex (CHD2, CHD3, CHD4, CHD7, CHD8), the BAF complex (SMARCA2,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42528014
DOI: 10.1002/cns.71061
PMCID: PMC13420320

Genes

ARID1B
CHD2
SMARCA2
ACTB
ARID2
BPTF
CHD3
CHD4
CHD7
CHD8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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