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Neurodevelopmental disorders, immunity, and cancer are connected

30 May 2022

Abstract excerpt

Immunity could be viewed as the common factor in neurodevelopmental disorders and cancer. The immune and nervous systems coevolve as the embryo develops. Immunity can release cytokines that activate MAPK signaling in neural cells. In specific embryonic brain cell types, dysregulated signaling that results from germline or embryonic mutations can promote changes in chromatin organization and gene accessibility,...

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PMID: 35712080
DOI: 10.1016/j.isci.2022.104492

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